Gastrogyl 100ml

Pronunciation

• GAS-troh-jel

Trade Name

• Gastrogyl

Classification

• Therapeutic: Antacid
• Pharmacologic: Combination of antacid and anti-ulcer agents

Pregnancy Category

• Category B (general classification, specific product components may vary)

Indications

• Relief of symptoms associated with hyperacidity, such as heartburn, acid indigestion, and upset stomach.
• Treatment and prevention of gastric and duodenal ulcers, gastritis, and gastroesophageal reflux disease (GERD).

Mechanism of Action

• Antacids (e.g., Aluminum hydroxide, Magnesium hydroxide): Neutralize stomach acid by increasing the pH of gastric contents.
• Anti-ulcer agents (e.g., Simethicone): May be included to relieve gas and bloating by reducing surface tension of gas bubbles, allowing easier passage.

Pharmacokinetics

• Absorption: Limited systemic absorption; primarily acts locally in the stomach.
• Distribution: Local effect in the gastrointestinal tract.
• Metabolism: Not significantly metabolized.
• Excretion: Excreted primarily in the feces.
• Half-life: Not applicable due to local action.

Contraindications and Precautions

• Contraindications: Hypersensitivity to any component of the formulation. Severe renal impairment due to the risk of aluminum or magnesium accumulation.
• Precautions: Use with caution in patients with kidney disease, as magnesium and aluminum can accumulate and cause toxicity. Long-term use may lead to electrolyte imbalances. Consult a healthcare provider if pregnant or breastfeeding.

Adverse Reactions and Side Effects

• Common: Constipation (due to aluminum hydroxide), diarrhea (due to magnesium hydroxide), nausea.
• Serious: Hypermagnesemia or hyperaluminemia in patients with renal impairment, allergic reactions (rash, itching, swelling), severe dizziness, difficulty breathing.

Interactions

• Drug-Drug: Can interfere with the absorption of other medications, such as tetracyclines, quinolones, and iron salts. Separate administration times by at least 2 hours.
• Food: No significant interactions, but antacids may affect the absorption of certain nutrients if used excessively.

Route/Dosage

• Oral (Suspension):
  • Adults: Typically, 10-20 ml taken 1-3 hours after meals and at bedtime, or as directed by a healthcare provider.
  • Pediatric Dosage: Should be determined by a healthcare professional based on age and weight.

Availability Formulations

• Gastrogyl Suspension: Available in 100 ml bottles as an oral suspension. Shake well before use.