Tridex Cough Mixture 100ml

Pronunciation

• TRY-dex

Trade Name

• Tridex Cough Mixture

Classification

• Therapeutic: Antitussive, Expectorant, Decongestant
• Pharmacologic: Combination of Dextromethorphan, Guaifenesin, and Phenylephrine

Pregnancy Category

• Category C

Indications

• Relief of coughs due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants.
• Helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.
• Relieves nasal congestion and sinus pressure.

Mechanism of Action

• Dextromethorphan: Suppresses the cough reflex by direct action on the cough center in the medulla.
• Guaifenesin: Acts as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi, facilitating the removal of mucus.
• Phenylephrine: Acts as a decongestant by constricting blood vessels in the nasal passages, reducing swelling and congestion.

Pharmacokinetics

• Absorption: Well absorbed from the gastrointestinal tract.
• Distribution: Widely distributed in body tissues.
• Metabolism:
  • Dextromethorphan: Metabolized in the liver to dextrorphan, an active metabolite.
  • Guaifenesin: Metabolized in the liver.
  • Phenylephrine: Metabolized in the liver and intestines.
• Excretion: Primarily excreted in the urine.
• Half-life:
  • Dextromethorphan: Approximately 2-4 hours.
  • Guaifenesin: Approximately 1 hour.
  • Phenylephrine: Approximately 2-3 hours.

Contraindications and Precautions

• Contraindications: Hypersensitivity to any component of the formulation. Concurrent use of MAO inhibitors or within 14 days of stopping such treatment. Severe hypertension, severe coronary artery disease.
• Precautions: Use with caution in patients with high blood pressure, heart disease, diabetes, thyroid disorders, enlarged prostate, or glaucoma. Avoid use in pregnant and breastfeeding women unless prescribed by a healthcare provider.

Adverse Reactions and Side Effects

• Common: Drowsiness, dizziness, nervousness, nausea, vomiting, stomach upset.
• Serious: High blood pressure, rapid heartbeat, palpitations, confusion, hallucinations, severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing).

Interactions

• Drug-Drug: Increased risk of hypertensive crisis with MAO inhibitors. May interact with other central nervous system depressants, antihypertensive drugs, and certain antidepressants.
• Food: No significant interactions, but avoid alcohol due to the risk of increased drowsiness and dizziness.

Route/Dosage

• Oral (Syrup):
  • Adults and children over 12 years: Typically, 10 ml every 4-6 hours as needed, not exceeding 60 ml in 24 hours.
  • Children 6-12 years: Typically, 5 ml every 4-6 hours as needed, not exceeding 30 ml in 24 hours.
  • Children under 6 years: Dosage should be determined by a healthcare professional.

Availability Formulations

• Tridex Cough Mixture: Available in 100 ml bottles as an oral syrup. Shake well before use.