Dexneo Eye Drops 5ml

Pronunciation

• DEX-nee-oh

Trade Name

• Dexneo Eye Drops

Classification

• Therapeutic: Anti-inflammatory and antibiotic combination
• Pharmacologic: Corticosteroid and aminoglycoside

Pregnancy Category

• Category C

Indications

• Treatment of eye infections and inflammation.
• Used to reduce swelling, redness, and discomfort in eye conditions responsive to steroids and antibiotics.

Mechanism of Action

• Dexamethasone: A corticosteroid that works by inhibiting inflammatory responses, thereby reducing swelling, redness, and pain.
• Neomycin: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, leading to the death of susceptible bacteria.

Pharmacokinetics

• Absorption: Topical application results in minimal systemic absorption, primarily localized to the site of application.
• Distribution: Limited to the application site; systemic distribution is minimal.
• Metabolism: Dexamethasone is metabolized in the liver; neomycin is minimally absorbed and metabolized.
• Excretion: Excreted primarily in the urine.

Contraindications and Precautions

• Contraindications: Hypersensitivity to dexamethasone, neomycin, or any component of the formulation; viral or fungal infections of the eye; mycobacterial infection of the eye; untreated purulent eye infections.
• Precautions: Prolonged use can lead to increased intraocular pressure, glaucoma, cataracts, and secondary eye infections. Use with caution in patients with a history of herpes simplex eye infections.

Adverse Reactions and Side Effects

• Common: Temporary burning or stinging upon application, blurred vision.
• Serious: Increased intraocular pressure, glaucoma, cataracts, secondary infections, and hypersensitivity reactions.

Interactions

• Drug-Drug: Concurrent use with other corticosteroids may increase the risk of side effects. Use with other ototoxic or nephrotoxic drugs may increase the risk of toxicity.

Route/Dosage

• Ophthalmic (Eye Drops): The typical dosage for adults and children is 1-2 drops in the affected eye(s) 2-4 times daily. Dosage and frequency may vary based on the severity of the condition and the prescribing physician's instructions.

Availability Formulations

• Dexneo Eye Drops: Available as a sterile ophthalmic solution in 5ml dropper bottles.