Lacoff Original 100ml

Pronunciation

• LAY-koff

Trade Name

• Lacoff Original

Classification

• Therapeutic: Cough suppressant
• Pharmacologic: Combination of antitussive, expectorant, and/or antihistamine

Pregnancy Category

• Category C (general classification, specific product components may vary)

Indications

• Relief of cough and related symptoms associated with colds, upper respiratory tract infections, or allergies.

Mechanism of Action

• Antitussive (e.g., Dextromethorphan): Suppresses the cough reflex by acting on the cough center in the medulla of the brain.
• Expectorant (e.g., Guaifenesin): Helps thin and loosen mucus in the airways, making it easier to cough up the phlegm.
• Antihistamine (if present): Reduces allergy symptoms by blocking histamine receptors.

Pharmacokinetics

• Absorption: Well absorbed from the gastrointestinal tract.
• Distribution: Distributed throughout the body, crosses the blood-brain barrier (antitussive components).
• Metabolism: Metabolized in the liver.
• Excretion: Excreted primarily in the urine.
• Half-life: Varies based on the active ingredients (e.g., Dextromethorphan has a half-life of 2-4 hours).

Contraindications and Precautions

• Contraindications: Hypersensitivity to any component of the formulation; use with caution in patients with chronic cough due to smoking, asthma, or emphysema.
• Precautions: Use with caution in patients with liver disease, chronic bronchitis, or a history of drug abuse. Avoid using in children under 6 years without medical advice. Consult a healthcare provider if pregnant or breastfeeding.

Adverse Reactions and Side Effects

• Common: Drowsiness, dizziness, nausea, vomiting, gastrointestinal discomfort.
• Serious: Allergic reactions (rash, itching, swelling), difficulty breathing, hallucinations (with high doses of dextromethorphan), serotonin syndrome (when combined with other serotonergic drugs).

Interactions

• Drug-Drug: May interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), and other CNS depressants. Can increase the risk of serotonin syndrome when combined with serotonergic drugs.
• Food: Generally, no significant interactions, but alcohol should be avoided due to increased risk of CNS depression.

Route/Dosage

• Oral (Syrup): The typical adult dose varies based on the specific active ingredients. For example, a common dose for dextromethorphan is 10-20 mg every 4 hours or 30 mg every 6-8 hours. Guaifenesin is typically dosed at 200-400 mg every 4 hours as needed. Always follow the dosing instructions on the product label or as prescribed by a healthcare provider.
• Pediatric Dosage: Should be determined by a healthcare professional based on age and weight.

Availability Formulations

• Lacoff Original Syrup: Available in 100 ml bottles as an oral syrup. Shake well before use.